The Road Runner Show was comprised of original theatrical short from the 40s, 50s and 60s about Wile E. Coyote and Road Runner, two of Warner Bros.' most popular cartoon characters. The characters were created by animation legend Chuck Jones and were forever locked in a life-or-injury battle that consistently ended with Coyote's spectacular pratfalls.

Set in the Southwest desert landscape, Coyote's schemes and inventions all served his unrelenting obsession: to catch the fast Road Runner bird. Wile E. was no match for the Road Runner's speed but what he lacked in physical prowess, he made up in cleverness and ingenuity. Countless traps were set out on the road or the desert, designed to lure the speedy bird into the coyote's clutches. Wile E. routinely resorted to mail order gizmos from the Acme company that involved rockets, dynamite or both in an effort to catch up to the Road Runner. The hunter was plagued with perpetual bad luck because he always fell into his own snares, blew himself up, plunged off a cliff or all three. At the same time.

The anthology of shorts aired on CBS for two season and then on ABC for one more, featuring two Coyote/Road Runner segments per episode, separate by a short starring other Warner Bros. cartoon characters like Sylvester and Tweedy Bird. The show hadn't lost its appeal and continued in reruns throughout the 70s and 80s.